Research Paper
Development and evaluation of nano-encapsulated curcumin chewable tablets
Herbal medicine is the oldest form of healthcare known to mankind and Turmeric is one of the oldest known herbs used in Asian countries since 2000 years ago. Curcumin is a plant-derived polyphenolic compound, naturally present in turmeric (Curcuma longa), has been the subject of intensive investigations on account of its various activities. In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. It is insufficiently absorbed in the human body, it has high metabolism speed and high elimination from the human body. For overcome these effects nano technology are applied on curcumin for enhancing the bioavailability of curcumin in the human body. Curcumin contains medical benefits. These benefits provided to a human in the form of a chewable tablet. Chewable tablets are required to be broken and chewed in between the teeth before ingestion. These tablets are given to the children who have difficulty in swallowing and to the adults who dislike swallowing. Chewable tablets are a help to improved patient acceptance (especially pediatric) through pleasant taste, patient convenience; need no water for swallowing, absorption of the drug is faster, better bioavailability through bypassing disintegration (that increase dissolution), the large size of the dosage form is difficult to swallow. In such cases, chewable tablet offers advantages over it. The aim of this study was to develop a nanocurcumin chewable tablet which can provide promising results for curcumin to improve its biological activities. Tablet was evaluated for Weight variation test, Friability, Hardness and Time required for complete chewing and are found to be within acceptable limits.
Published by: Kislay Baranwal, Hina Khan, Himanshu Kashudhan
Author: Kislay Baranwal
Paper ID: V4I3-1468
Paper Status: published
Published: May 19, 2018
Full Details