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Product quality by process analytical technology and quality by design- A short communication

A Systematic approach which is based on scientific knowledge and concept of quality risk management which leads to development which emphasizes on process and product undertaking an starts with a predefined objectivesis usually called as QBD,which now aims at pharmaceutical development to design a quality product and the entire manufacturing process aiming to produce according to the standard and specifications to consistentely deliver product intended,the knowledge is purely base on scientific approach,qbd is not only limited to production but is also extended to analytical proceures and methodology,the article relates to a short communication about A QBD its approach, history and its basic elements.The product procedures now need to comply till the end of the entire procedure s rather than only at the begining and that’s where QbD plays important role throughout the method life cycle also it give added advantage is to include the procedure to discovering and minimizing the sources of viability which may lead to inferior quality and procedure and products.

Published by: Anita A., Vinod Mathew, Sapna Dongre, Akshata

Author: Anita A.

Paper ID: V6I3-1157

Paper Status: published

Published: May 7, 2020

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Research Paper

Border surveillance robot

Border monitoring is a complex challenge, it requires protection all day, all night, and in all conditions. Border security is required to monitor the area every second and detect unusual activities, this is generally being carried out by human effort, but humans are prone to errors due to fatigue or exhaustion. Border surveillance robot comes up with special surveillance, scanning the area continuously in real-time. This monitoring greatly decreases the erroneous human monitoring. The proposed system provides real-time video footage and ensures protection from terrorists or any kind of prohibited intrusion.

Published by: Sabiya Sultana, D. Shalini, Prashanth Varma, V. Sri Charan, B. Shiva Kumar

Author: Sabiya Sultana

Paper ID: V6I3-1156

Paper Status: published

Published: May 7, 2020

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Review Paper

Design and analysis of pharma tableting radial tools cavity for material optimization- A review

There are lot of reasons for tablet defects whether it comes from upstream or from tablet press. The poor quality of raw materials or not complying with standards, resulting in unnecessary fines leading to a host of defects. The formulation may be a source of defect if the material does not compress well or if the processing phase stated in the formulation fails to produce a good flow of powder; Tablet press operators, however, don‘t have any control over formulation and granulation. Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, capping, lamination, variable hardness, among others. This article focuses on these variations. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems. When tablet is free from visual defect or functional defect then we can say that it is an ideal tablet. The advancements and innovations in tablet manufacture have not decreased the problems, often encountered in the production, instead have increased the problems, mainly because of the complexities of tablet presses; and/or the greater demands of quality. An industrial pharmacist usually encounters number of problems during manufacturing. Majority of visual defects are due to inadequate fines or inadequate moisture in the granules ready for compression or due to faulty machine setting. Functional defects are due to faulty formulation. Solving many of the manufacturing problems requires an in–depth knowledge of granulation processing and tablet presses, and is acquired only through an exhaustive study and a rich experience.

Published by: Prathamesh Preetam Choughule, Satish Silaskar, Pravin Alone

Author: Prathamesh Preetam Choughule

Paper ID: V6I3-1160

Paper Status: published

Published: May 7, 2020

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Research Paper

Formulation, development and evaluation of Polysaccharide based Gastro-retentive Formulation for Delivery of Anti-Hypertensive Drug

In situ gel-forming systems have been widely investigated as vehicles for sustained drug delivery. In situ gel formation occurs due to one or a combination of different stimuli like pH change, temperature modulation, and solvent exchange. So, In situ gelling system via different routes such as oral, nasal, ophthalmic, etc can be formulated. In the present research work Oral Floating Insitu gel of Captopril was formulated using Sodium alginate. The optimized batch gave drug release for 7 hrs in the polymer combination of Sodium Alginate 1% and sodium bicarbonate 1.25%. It was found to be floating for more than 12 hrs. The batch was found to be stable for 2 months of instability study.

Published by: Dr. Gyati Shilakari Asthana, Kavi Soundarya, Vemula Nagamani

Author: Dr. Gyati Shilakari Asthana

Paper ID: V6I2-1341

Paper Status: published

Published: May 7, 2020

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Others

Improving the performance of patch antenna using microwave frequency bands

The microstrip patch antennas have limited gain and bandwidth performance. In this paper, an enhancement in the gain, bandwidth, VSWR, return loss and directivity this will make antenna more compact and low profile and this parameter is achieved by slotting an ECE radiating patch and using a defected ground structure and by using proximity feeding and also by techonicCER-10 substrate respectively. The proposed antenna design with a design frequency of 2.45 GHz, (4 to 8)GHz, (8-12)GHz, (26-40)GHz has been evolved isometrically in different designs stages (design iterations). The work of single-band antenna with a slotted patch geometry offering an improved gain but limited in its bandwidth. The change in the widths of the ground, substrate, and the patch along with the addition of slots into this design results in a completely different geometry featuring multi-band operation with an improved parameter performance and the use of defected ground structure in the final stage counters the limited bandwidth operability. All the involved iteration designs have been simulated over CST 2019 for the performance parameters of the reflection coefficient, bandwidth, radiation pattern and gain, VSWR, return loss. The measured results have been found to be in close approximation to the simulated ones.

Published by: Pallapu Satish Kumar, S. Leela Krishna, M. Shiva Prasad, T. Yashwanth

Author: Pallapu Satish Kumar

Paper ID: V6I3-1155

Paper Status: published

Published: May 4, 2020

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Others

Intelligent healthcare and monitoring system using Internet of Things for railway passengers

Among different modes of transportation, railway transportation offers reduced travel time, dependability, and excellent energy conservation. Invariably, this mode of transportation plays a vital role not only in the transportation of goods and commodities but also helps in the passenger itinerary. Many technological developments have ascended in the field of railways but healthcare is a major concern. Internet of Things(IoT) is a revolutionary technology that is being widely used to integrate advanced medical resources thereby offering effective health care services to human beings in an effortless way. In this project, we are proposing a controller-based technique to give first aid support in case of emergency, to the patients who are in immediate requirement of medical assistance. The abnormality is detected with the help of wearable sensors. Once the abnormality is detected, the first aid system is triggered by life. The information is transferred to the loco pilot who is in charge of operating the train and the nearest station. Thus, with the help of this system, we will be able to save the life of patients in case of an emergency during transit.

Published by: Chandana T., Anugraha S., Deepika U., Tamil Arasi K.

Author: Chandana T.

Paper ID: V6I3-1153

Paper Status: published

Published: May 4, 2020

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