Promoting health, wellness, and disease prevention is increasingly vital in today's changing society. This study aimed to enhance the knowledge of school children regarding first aid and safety measures through a structured teaching programme to prepare them for future emergencies. A quasi-experimental research design was utilized, involving a sample of 100 school children selected via convenient sampling from schools in District Mandi, Himachal Pradesh. Data analysis was conducted using descriptive and inferential statistics. The pre-test mean knowledge scores were comparable between the control (9.68) and experimental (9.9) groups. Following the intervention, the control group’s post-test mean score remained statistically stagnant at 9.46, whereas the experimental group’s mean score significantly increased to 25.5. This massive improvement in the experimental group was statistically significant (t-value = 33.92, surpassing the critical table value of 2.021 at p < 0.05). Additionally, post-test knowledge in the experimental group showed significant associations with age, school type, maternal education, and paternal occupation. The structured teaching programme had a highly significant positive impact on improving first aid and safety knowledge among school children.