This paper is published in Volume-4, Issue-3, 2018
Area
Biotechnology
Author
S. Venkatesh, Lokesh Ravi, Appadurai Rajendran
Org/Univ
National Institute of Ocean Technology, Chennai, Tamil Nadu, India
Pub. Date
26 May, 2018
Paper ID
V4I3-1582
Publisher
Keywords
Melanin, E-coli, Porphyromonas gingivalis, Oral pathogen, Gingivitis, Biofilm formation, Inflammatory response, A cyclooxygenase-2 enzyme

Citationsacebook

IEEE
S. Venkatesh, Lokesh Ravi, Appadurai Rajendran. Role of oral mucosal melanin-from birth to adulthood in primary preference. Antibacterial, antifungal and antibiofilm but not anti-inflammatory activity, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
S. Venkatesh, Lokesh Ravi, Appadurai Rajendran (2018). Role of oral mucosal melanin-from birth to adulthood in primary preference. Antibacterial, antifungal and antibiofilm but not anti-inflammatory activity. International Journal of Advance Research, Ideas and Innovations in Technology, 4(3) www.IJARIIT.com.

MLA
S. Venkatesh, Lokesh Ravi, Appadurai Rajendran. "Role of oral mucosal melanin-from birth to adulthood in primary preference. Antibacterial, antifungal and antibiofilm but not anti-inflammatory activity." International Journal of Advance Research, Ideas and Innovations in Technology 4.3 (2018). www.IJARIIT.com.

Abstract

Human tissues containing melanocytes secreting melanin pigments contributes a low-level protection of the skin and hair follicles against many factors, but in oral mucosa, the melanin levels and functions vary with a microbial environment which is an unknown mechanism and its role is still not fully understood, especially defense against the oral pathogens in the mucosa. This study addresses a possible role of melanin has a multifunctional activity to protect the gingiva during child to adult age by exploring, the mechanism of interaction with oral bacteria, fungus, biofilm-forming bacteria and inflammatory cox-2 proteins using in-silico analysis. Our results showed, human oral mucosa containing melanin act as a antagonist against DHPS containing E.coli and S.aureus (antibacterial), ScNMT in S.cerevisae (antifungal), quorum sensing P.aeruginosa containing LasA (antibiofilm property), except human COX-2 not showed an anti-inflammatory activity and the binding energies for melanin with DHPS of E.coli and S.aureus (-8.9 and -7.1 kcal/mol) respectively, melanin with ScNMT (-8.0 kcal/mol), P.aeruginosa (LasA) (-8.3 kcal/mol) and Cycloxygenase-2 with melanin (-10.3 kcal/mol). We explored the importance of oral mucosa containing melanin with broad-spectrum activity against oral pathogen with no anti-inflammatory activity based on the route of transmission, the oral pathogens select for their survival in the gingiva and tooth during the different stage ages of humans.