This paper is published in Volume-4, Issue-4, 2018
Area
Pharmaceutics
Author
Sivaranjani Ganapathy, Dr. R. Suja, Dr. P. G. Latha, Dr. B. S. Bijukumar, Dr. V J Shine, Dr. P Shikha, Dr. Sreejith G
Org/Univ
Annamalai University, Chidambaram, Tamil Nadu, India
Pub. Date
21 August, 2018
Paper ID
V4I4-1492
Publisher
Keywords
Vitex Altissima, Stem Bark, Anti-Inflammatory, Analgesic, Toxicity, Ethanolic Extract

Citationsacebook

IEEE
Sivaranjani Ganapathy, Dr. R. Suja, Dr. P. G. Latha, Dr. B. S. Bijukumar, Dr. V J Shine, Dr. P Shikha, Dr. Sreejith G. Phytochemical analysis, Anti-inflammatory and Analgesic activity of Vitex altissima L.f. stem bark, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Sivaranjani Ganapathy, Dr. R. Suja, Dr. P. G. Latha, Dr. B. S. Bijukumar, Dr. V J Shine, Dr. P Shikha, Dr. Sreejith G (2018). Phytochemical analysis, Anti-inflammatory and Analgesic activity of Vitex altissima L.f. stem bark. International Journal of Advance Research, Ideas and Innovations in Technology, 4(4) www.IJARIIT.com.

MLA
Sivaranjani Ganapathy, Dr. R. Suja, Dr. P. G. Latha, Dr. B. S. Bijukumar, Dr. V J Shine, Dr. P Shikha, Dr. Sreejith G. "Phytochemical analysis, Anti-inflammatory and Analgesic activity of Vitex altissima L.f. stem bark." International Journal of Advance Research, Ideas and Innovations in Technology 4.4 (2018). www.IJARIIT.com.

Abstract

The present studies were designed to evaluate the anti-inflammatory and analgesic activity of ethanolic extract of Vitex altissima stem bark (Peacock Chaste tree). The anti-inflammatory activity was evaluated by in vivo models like carrageenan-induced rat hind paw edema and Acetic acid induced vascular permeability in mice using dose levels of 150 and 450 mg/kg body weight (orally) for ethanolic extract of Vitex altissima and compared to reference drugs indomethacin (10 mg/kg body weight, orally). The analgesic activity was evaluated by in vivo models like an acetic acid-induced writhing assay in mice using dose levels of 150 and 450 mg/kg body weight (orally) for ethanolic extract of Vitex altissima and compared to reference drugs acetylsalicylic acid (25 mg/kg body weight, orally). Acute toxicity study of the extract was performed prior to studies. The ethanolic extract of the stem bark of Vitex altissima showed significant dose-dependent anti-inflammatory and analgesic properties. The acute toxicity study indicated that the plant was non-toxic up to the dose level (<5g/kg). On the basis of obtained results, it was concluded that the ethanolic extract of the stem bark of Vitex altissima can be marked as a potent candidate for the management of inflammatory diseases and pain.