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To investigate potential target based phytochemicals against COX 2 & STAT 3 protein of Squamous Cell Carcinoma of Head & Neck using In-Silico approach

Cancer is not just one disease but many diseases affecting the world over. Carcinoma is a type of cancer arise from epithelial cells. Squamous-cell carcinoma of the head and neck (SCCHN) represents a heterogeneous disease entity, with various etiological factors implicated in the genesis of distinct molecular subsets of tumors, which exhibit different biological and clinical behavior. Historically, SCCHN has been about twice as common in men as in women and more frequent in people over 50 with growing incidence reported among younger people. Alcohol and tobacco are common etiologic factors for SCCHN, linked to at least 75% of cases. Systems biology emphasizes the need for molecular characterization of cancer development. Molecular tools are screened as means of candidate biomarkers leading to cancer. Overexpression of proteins causing tumorigenesis is better understood by studying their role in cancer proliferation. COX 2 and STAT3 are pathway-mediated bioagents in head and neck cancer considered as targetable protein. Phytochemicals such as Rutin, Quercetin and Ellagic acid are well-known inhibitors of both COX 2 and STAT3 proteins. In-silico approach was used to analyze binding interactions of phytochemicals against selected protein structures of COX 2 and STAT3 using docking studies thereby forming drug able agents. The main objective is to find an alternative treatment to chemoprevention therapy. This research work aims to carry out systematic review of head and neck cancer in order to develop potential target-based therapy. Therefore, Rutin against 5IKR, 5F19, Quercetin against 6NJS and Ellagic acid against 6QHD may be considered to be potential anti-cancer against SCCHN target which further needs to be explored for drug development process.

Published by: Priyankal D. Sharma, Aparna Hiren Patil Kose, Chintan Navnit Shah

Author: Priyankal D. Sharma

Paper ID: V6I3-1627

Paper Status: published

Published: June 26, 2020

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A descriptive study to assess the knowledge and attitude of cervical cancer and its prevention among the married women residing in selected Bhattakuffer area, Shimla, Himachal Pradesh

Cervical cancer remains a major cause of morbidity and mortality among women worldwide and an issue of significant public health concern. HPV is a necessary cause of cervical cancer, but it is not a sufficient cause. The burden of cervical cancer in India is enormous accounting for about 20 percent of all cancer-related deaths in women and is the number one cause of death in the middle age of Indian women. Objectives of the study were to (1) To assess the knowledge of married women regarding cervical cancer. (2) To assess the attitude of married women regarding cervical cancer. (3) To find out the association between attitude and knowledge score related to cervical cancer with their socio-demographic variables. Methods: The descriptive research design was adopted to collect the data from 100 married women residing in the selected community area of Shimla, Himachal Pradesh via using a random sampling technique. The data was collected by a self-structured questionnaire and by using a 5-Point Likert scale. Result: The findings of the study show that about 79% of women were having moderate knowledge who scored (21-31marks) and 11 % were inadequate who scored (11-20marks) and 10% (0-10 marks) of the married women were having adequate knowledge regarding cervical cancer and its prevention. The majority of the married women were having a neutral attitude (71%), and (29%) of the women were having a positive attitude towards cervical cancer and its prevention. cer

Published by: Diksha Sharma, Chanchal Sharma

Author: Diksha Sharma

Paper ID: V6I3-1620

Paper Status: published

Published: June 26, 2020

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Research Paper

Photocatalytic decolourization of congo red dye from aqueous solution by fungal biomass doped copper oxide nanoparticles

Dye-containing wastewater discharged from several industrial activities is a serious threat to the water bodies around industrial areas, because these toxic, organic or synthetic, dyes can affect plant life and human life indirectly affecting the ecosystem of the environment. The study was aimed to enhance the capacity of the biosorption process by doping copper oxide on to fungal biomass for dye remediation. The isolated fungal strain is Aspergillus flavus. Copper oxide nanoparticles are synthesized by green synthetic pathway and Coriandrum sativum was utilized as 0.04 M Copper oxide and fungal biomass

Published by: Praveen Kumar, Evanjalin Monica

Author: Praveen Kumar

Paper ID: V6I3-1578

Paper Status: published

Published: June 26, 2020

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Review Paper

Redefining the gravity

Abstract A falling object does not have weight, but only moving force, a moving object has fixed uniform motion ( see proof ahead ), it neither accelerates nor retards during falling towards Earth. So every particle on earth has a uniform value of inertia. Every particle on earth tends to move towards the centre of the earth as each particle has a direction towards the centre but as compared to space each and every direction of particles may be considered as having single infinite side. These forces indicate us all about earth circumstances and prevailing at its beginning. We will take into consideration the mass of earth before collection coming into existence. The weight which we feel on the surface of the earth is actually a force which tends to move. Objects do not fall due to attraction of earth but due to their own force which we feel as weight. There is no acceleration while falling of an object compared with a 3D Graph of space. The falling path of an object is actually curved. All force of earth has alignment towards a single central point. The force which we feel as weight is responsible for retraction of earth towards the centre but not due to attraction. There is nether attraction between two points on earth nor between any object and earth.

Published by: Abdul Qayoom Dar

Author: Abdul Qayoom Dar

Paper ID: V6I3-1597

Paper Status: published

Published: June 26, 2020

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Effectiveness of childbirth education on knowledge and childbirth experience among Primigravida Women: A quasi-experimental study

Introduction: Pregnancy is the term used to describe the period in which a fetus develops inside a woman's womb or uterus. Pregnancy usually lasts about 40 weeks or just over 9 months as measured from the last menstrual period to delivery. The experience of childbirth is always linked with emotional feelings and expectations. Objective: The aim of the study was to assess the effectiveness of childbirth education on knowledge and childbirth experience among primigravida women Methods: A quasi-experimental design was used to assess the effectiveness of childbirth education on knowledge and childbirth experience among primigravida women in Kamla Nehru Hospital, Shimla. In this study Pre-test and Post-test control group design, 50 primigravida women (25 in the experimental group and 25 in the control group), gestational age of 36- 38 weeks. Self Structured knowledge questionnaire to assess the knowledge and childbirth expectancy was measured by using Wijma Delivery expectancy questionnaire (scale-A) before the intervention in both group and childbirth experience was measured by using Wijma delivery experience questionnaire (scale-B) was used for data collection. Data was collected by structure interview schedule and analyzed by using descriptive and inferential statistics. Results- In experimental group pre-test mean±SD knowledge score was (8.60±1.38) and post-test mean±SD knowledge score was (14.12±1.81). The difference between pre-test and post-test mean±SD knowledge score was highly significant p=0.001. In the control group pre-test mean±SD knowledge score was (9.00±1.38) and post-test mean±SD knowledge score was (9.24±1.39). The difference between pre-test and post-test mean knowledge score was statistically non-significant. childbirth expectancy score of the experimental group was found to be (75.00±7.11) and the childbirth expectancy score of the control group was found to be (81.12±3.27). Whereas the childbirth experience score of the experimental group was found to be (60.40±2.87) and childbirth experience score of the control group was found to be (80.68±2.97) which was statistically significant at the level of 0.001. It was concluded that Childbirth education had an impact on knowledge and childbirth experience among primigravida women. Conclusion: The study findings implied that the implementation of childbirth education has an essential role to increase knowledge and improved childbirth experience of primigravida women.

Published by: Rohini Rajpoot, Jaswinder Kaur

Author: Rohini Rajpoot

Paper ID: V6I3-1618

Paper Status: published

Published: June 26, 2020

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Research Paper

Permutation series and combination series

The Permutation Series and Combination Series will ensure the readers to understand the proper calculation of Permutation and Combination and will also help them to grow their knowledge on the topic. It is a very helpful topic for the students to strengthen their roots in mathematics. The magic that Mathematics has in it will be exposed to the readers to understand their Mathematics thoroughly and will also help them to enlarge their thinking capabilities. Hence, this topic is very interesting as it provides a link between A.P, G.P with Permutation, and Combination. It will help to calculate many selections and others in a very small time.

Published by: Swarnav Majumder

Author: Swarnav Majumder

Paper ID: V6I3-1617

Paper Status: published

Published: June 26, 2020

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