This research paper explores depression among high school students and its impact on their mental well-being and academic experiences. It examines how adolescent depression is influenced by multiple interconnected factors, including family environment, school pressure, peer relationships, psychological characteristics, biological vulnerability, and cultural and societal influences. The paper highlights the importance of understanding depression within school settings and emphasizes the need for supportive environments, early awareness, and combined efforts from schools, families, and communities to promote adolescent mental health.