Artificial organs have been at the frontier of modern excitement in medicine for several reasons: the increasing prevalence of organ failure, limitations to transplantation, and advances in biomedical engineering. In this regard, the following is a concerning overview of artificial organs, including the development materials and technologies, investigations into individual artificial organs, and their wider clinical and technological contexts. Such discussions state that, insofar as artificial organs have many advantages and their limitations and challenges, there is a strong need for these kinds of emerging technologies to meet the enormous healthcare demands that have outpaced supply from donors. The present paper reviews cutting-edge developments and possible futures within the artificial organ research field, particularly focusing on the development of bioartificial and hybrid systems combining synthetic components with living biological systems. This review provides an objective overview of where the field stands regarding the development of artificial organs within regenerative and reparative medicine and, more importantly, where it could head in the next couple of decades.