Skin cancer most basic malignancy nowadays. Distinctive remedial methodology for the treatment of skin disease as of now being examined. Cannabinoids delta THC is a dynamic cannabinoid utilized as a part of the different tumor and furthermore, in various malady like Parkinson's disorder, AIDS incite emesis. Cannabinoids have two subtypes of cannabinoids receptors CB1 & CB2 we examined the potential utility of these compound in skin tumor in mice by the B-16 cell line. Where both petroleum ether and ethanolic extract of cannabis Sativa give better reaction by treatment of tumor-bearing mice. This went with by an impedance of tumor vascularization, as controlled by adjusted vein morphology and diminished articulation of proangiogenic factors (VEGF, placental development factor, and angiopoietin 2). Repeal of EGF-R work was additionally seen in cannabinoid-treated tumors. These outcomes bolster another remedial approach for the treatment of skin tumors.