This paper is published in Volume-3, Issue-6, 2017
Area
Pharmacy
Author
SDVS Kiran
Co-authors
Venkateswara Rao .P, Rohini .P, Bhagyasree .P
Org/Univ
Global Pharmacovigilence, MSN Labs, Hyderabad, Telangana, India
Pub. Date
15 November, 2017
Paper ID
V3I6-1239
Publisher
Keywords
Naringenin, 3-Nitropropionic Acid, Huntington’s Disease, Oxidative Stress.

Citationsacebook

IEEE
SDVS Kiran, Venkateswara Rao .P, Rohini .P, Bhagyasree .P. Effect of Naringenin on 3-NP Induced Huntington’s Disease like Symptoms by Estimations of Motor Co-ordination and Behavioral Parameters, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
SDVS Kiran, Venkateswara Rao .P, Rohini .P, Bhagyasree .P (2017). Effect of Naringenin on 3-NP Induced Huntington’s Disease like Symptoms by Estimations of Motor Co-ordination and Behavioral Parameters. International Journal of Advance Research, Ideas and Innovations in Technology, 3(6) www.IJARIIT.com.

MLA
SDVS Kiran, Venkateswara Rao .P, Rohini .P, Bhagyasree .P. "Effect of Naringenin on 3-NP Induced Huntington’s Disease like Symptoms by Estimations of Motor Co-ordination and Behavioral Parameters." International Journal of Advance Research, Ideas and Innovations in Technology 3.6 (2017). www.IJARIIT.com.

Abstract

The main aim of this study was to investigate the effect of Naringenin, a flavonoid on 3-Nitropropionic acid (3-NP)-induced Huntington’s disease like symptoms by estimations of motor co-ordination and behavioral parameters. 3-NP is an irreversible inhibitor of complex II in the mitochondria. 3-NP-induced neurodegeneration has been widely used as an animal model of Huntington’s disease (HD). It replicates the pathology of HD by causing oxidative stress. Naringenin is a polyphenolic compound, a bioflavonoid, known to have a neuroprotective effect in a rat model of Alzheimer’s disease. In the present study, the neuroprotective effect of Naringenin on 3-NP induced oxidative stress in rat was determined by behavioral parameters. Rats were induced with 3-NP (15 mg/kg) intraperitoneally for 21 days and rats induced with 3-NP were treated with Naringenin (25mg/kg and 75mg/kg) for 21 days. 3-NP caused a decline in motor function in neurological score, locomotor activity and impaired rotarod activity. Naringenin treatment significantly improved grip strength indicating an improvement in motor performance, alterations in % spontaneous alternations. These findings suggest the antioxidant potential of Naringenin flavonoid against 3-Nitropionic acid induced neurotoxicity. However, more investigations are required to elucidate the cellular mechanisms of Naringenin against 3-Nitropropionic acid induced Huntington’s disease like symptoms. Keywords: Naringenin, 3-Nitropropionic acid, Huntington’s disease, oxidative stress.
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