This paper is published in Volume-6, Issue-3, 2020
Area
Mechanical Engineering
Author
Prathamesh Preetam Choughule
Co-authors
Satish Silaskar, Pravin Alone
Org/Univ
New Horizon Institute of Technology and Management, Thane, Maharashtra, India
Pub. Date
06 May, 2020
Paper ID
V6I3-1160
Publisher
Keywords
Punches, Compression, Tablet Tool and Die Design, Tablet Defects

Citationsacebook

IEEE
Prathamesh Preetam Choughule, Satish Silaskar, Pravin Alone. Design and analysis of pharma tableting radial tools cavity for material optimization- A review, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Prathamesh Preetam Choughule, Satish Silaskar, Pravin Alone (2020). Design and analysis of pharma tableting radial tools cavity for material optimization- A review. International Journal of Advance Research, Ideas and Innovations in Technology, 6(3) www.IJARIIT.com.

MLA
Prathamesh Preetam Choughule, Satish Silaskar, Pravin Alone. "Design and analysis of pharma tableting radial tools cavity for material optimization- A review." International Journal of Advance Research, Ideas and Innovations in Technology 6.3 (2020). www.IJARIIT.com.

Abstract

There are lot of reasons for tablet defects whether it comes from upstream or from tablet press. The poor quality of raw materials or not complying with standards, resulting in unnecessary fines leading to a host of defects. The formulation may be a source of defect if the material does not compress well or if the processing phase stated in the formulation fails to produce a good flow of powder; Tablet press operators, however, don‘t have any control over formulation and granulation. Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, capping, lamination, variable hardness, among others. This article focuses on these variations. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems. When tablet is free from visual defect or functional defect then we can say that it is an ideal tablet. The advancements and innovations in tablet manufacture have not decreased the problems, often encountered in the production, instead have increased the problems, mainly because of the complexities of tablet presses; and/or the greater demands of quality. An industrial pharmacist usually encounters number of problems during manufacturing. Majority of visual defects are due to inadequate fines or inadequate moisture in the granules ready for compression or due to faulty machine setting. Functional defects are due to faulty formulation. Solving many of the manufacturing problems requires an in–depth knowledge of granulation processing and tablet presses, and is acquired only through an exhaustive study and a rich experience.
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