This paper is published in Volume-4, Issue-4, 2018
Area
Biopharmaceutics And Pharmacology
Author
Somnath Raosaheb Thanage
Co-authors
Dr. Bhawar Sanjay B., Dr. Dighe Santosh
Org/Univ
Pravara Rural College of Pharmacy, Ahmednagar, Maharashtra, India
Pub. Date
23 July, 2018
Paper ID
V4I4-1243
Publisher
Keywords
Buccal delivery, Increased released, Hypertension, Stress.

Citationsacebook

IEEE
Somnath Raosaheb Thanage, Dr. Bhawar Sanjay B., Dr. Dighe Santosh. A research on formulation and evaluation chewing gum of Simvastatin, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Somnath Raosaheb Thanage, Dr. Bhawar Sanjay B., Dr. Dighe Santosh (2018). A research on formulation and evaluation chewing gum of Simvastatin. International Journal of Advance Research, Ideas and Innovations in Technology, 4(4) www.IJARIIT.com.

MLA
Somnath Raosaheb Thanage, Dr. Bhawar Sanjay B., Dr. Dighe Santosh. "A research on formulation and evaluation chewing gum of Simvastatin." International Journal of Advance Research, Ideas and Innovations in Technology 4.4 (2018). www.IJARIIT.com.

Abstract

In the present era, many research and technological advancements are made in the field of oral drug delivery as it is highly accepted amongst patient. In this research the formulation of antihyperlipidemic chewing gum of simvastatin using water-insoluble gum base water-soluble other portion containing drug as well as excipients like taste masking agent sorbitol which use as a coating agent in this formulation. The primary and important requirement in the formulation of simvastatin chewing gum is the gum base, which gives it gummy texture for chewing action and as a drug vehicle.T his gum is isolated from the natural sources like a sapodilla moniker tree (Chiku) which fully grow in the Maharashtra region. This gum base has a property as like other gum bases which are present in nature. For the improvement in the stability of that gum base, which is converted in the dry form by drying and adding filler as talc and emulsifier such lecithin which was freshly collected from egg yolk. By drying this mixture further it converts in a directly compressible gum base powder, which possesses all-important flow property which requires for direct compression. Direct compression is one of the best methods as compared to the molding method in the formulation of chewing gum. For direct compression in directly compressible gum require other additional excipients like antiadherant, anti-caking agent, lubricant, antioxidant, flavor, and sweetening, the coating agent (sorbitol). For evaluation of formulated chewing gum, all parameter is same as like tablet except in-vitro drug release performance. For this purpose, the disintegration apparatus was modified in such way that it continuously compress or crush the chewing gum as like our mastication activity in the mouth, resulting in releases of the drug in the salivary fluid and absorbance were calculate on UV-visible spectra. In this also study the effect of stroke & distance between jaws which gives the valuable information about drug release performance in various ages patient.
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