This paper is published in Volume-5, Issue-3, 2019
Area
Biotechnology
Author
Shivangi Modi
Co-authors
Kritika Mukherjee
Org/Univ
Thadomal Shahani Engineering College, Mumbai, Maharashtra, India
Pub. Date
21 May, 2019
Paper ID
V5I3-1403
Publisher
Keywords
Regeneration, Eisenia Fetida, lesion, Nanog, Lin 28, Isotroin, Metformin, Regulation of proteins, Lumbrokinase, Gag, CRT

Citationsacebook

IEEE
Shivangi Modi, Kritika Mukherjee. Project on assessment of effects of the pharmacological agents in the modulation of regenerative abilities in Eisenia Fetida, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Shivangi Modi, Kritika Mukherjee (2019). Project on assessment of effects of the pharmacological agents in the modulation of regenerative abilities in Eisenia Fetida. International Journal of Advance Research, Ideas and Innovations in Technology, 5(3) www.IJARIIT.com.

MLA
Shivangi Modi, Kritika Mukherjee. "Project on assessment of effects of the pharmacological agents in the modulation of regenerative abilities in Eisenia Fetida." International Journal of Advance Research, Ideas and Innovations in Technology 5.3 (2019). www.IJARIIT.com.

Abstract

Regeneration is repair and regrowth of the lost tissues or organs in response to injury. To unravel the process of regeneration, it is really important to understand the repair mechanism and proteins involved in the process of tissue repair as well as regrowth, factors affecting them and the regulation of those factors. The present study was conducted to firstly observe the modulation of those proteins using different pharmacological agents to check on the regenerative ability of Eisenia fetida by targeting oct ¾, Nanog and lin28. These genes and their regulatory product proteins respectively were found to be modulated using pharmacological agents like isotroin and Metformin. The other proteins which were involved in the regeneration process were expected to get illuminated in protein profiling on using these agents. By using Metformin and Isotroin which were involved in the regulation of proteins like oct-4 and lin-28 which were themselves involved in regeneration, we could detect the upregulation rather the complete production of other proteins like lumbrokinase, gag, CRT which were concluded to be responsible for the regeneration in Eisenia fetida.
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