The endocrine system plays a central role in maintaining homeostasis through hormonal regulation. Aging is associated with progressive dysregulation of several endocrine axes, resulting in widespread effects on metabolism, musculoskeletal integrity, immune function, mental health, etc. This paper examines the impact of aging on key systems, including the growth hormone–insulin-like growth factor-I axis (GH-IGF-I Axis), dehydroepiandrosterone (DHEA(S)), the hypothalamo–pituitary–adrenal axis (HPA Axis), menopause, and andropause. Understanding these hormonal changes is essential for addressing age-related morbidity and improving quality of life in older populations.