The hospitality and tourism industry is experiencing a profound transformation shaped by sustainability concerns, rapid technological advancements, and evolving consumer expectations. This paper explores the future trajectory of the sector with a particular emphasis on the role of start-ups in fostering sustainable tourism innovation. It examines how emerging technologies, novel business models, and environmentally responsible practices are redefining traditional tourism frameworks. The study integrates theoretical perspectives with practical insights derived from Indian start-up case studies to illustrate how innovation can drive sustainability. The findings indicate that start-ups are critical enablers of change, promoting resource efficiency, community engagement, and experiential tourism. The paper concludes by outlining strategic recommendations for stakeholders to achieve long-term resilience and sustainability in hospitality and tourism.