This paper is published in Volume-6, Issue-2, 2020
Area
Pharmaceutics
Author
Dr. Gyati Shilakari Asthana
Co-authors
Kavi Soundarya, Vemula Nagamani
Org/Univ
Gokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, India
Pub. Date
07 May, 2020
Paper ID
V6I2-1341
Publisher
Keywords
Captopril, In-situ gel, In-vitro study

Citationsacebook

IEEE
Dr. Gyati Shilakari Asthana, Kavi Soundarya, Vemula Nagamani. Formulation, development and evaluation of Polysaccharide based Gastro-retentive Formulation for Delivery of Anti-Hypertensive Drug, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Dr. Gyati Shilakari Asthana, Kavi Soundarya, Vemula Nagamani (2020). Formulation, development and evaluation of Polysaccharide based Gastro-retentive Formulation for Delivery of Anti-Hypertensive Drug. International Journal of Advance Research, Ideas and Innovations in Technology, 6(2) www.IJARIIT.com.

MLA
Dr. Gyati Shilakari Asthana, Kavi Soundarya, Vemula Nagamani. "Formulation, development and evaluation of Polysaccharide based Gastro-retentive Formulation for Delivery of Anti-Hypertensive Drug." International Journal of Advance Research, Ideas and Innovations in Technology 6.2 (2020). www.IJARIIT.com.

Abstract

In situ gel-forming systems have been widely investigated as vehicles for sustained drug delivery. In situ gel formation occurs due to one or a combination of different stimuli like pH change, temperature modulation, and solvent exchange. So, In situ gelling system via different routes such as oral, nasal, ophthalmic, etc can be formulated. In the present research work Oral Floating Insitu gel of Captopril was formulated using Sodium alginate. The optimized batch gave drug release for 7 hrs in the polymer combination of Sodium Alginate 1% and sodium bicarbonate 1.25%. It was found to be floating for more than 12 hrs. The batch was found to be stable for 2 months of instability study.
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