Good health is central to human happiness and well-being that contributes significantly to prosperity and wealth and even economic progress, as healthy populations are more productive, save more and live longer. Telemedicine is the exchange of medical information from one location to another using electronic communication, which improves patient health status. This study aimed to assess the effectiveness of structured teaching programme in improving the knowledge regarding telemedicine among nursing students. Objectives: To assess the level of knowledge regarding telemedicine among nursing students. To evaluate the effectiveness of structured teaching program on knowledge regarding telemedicine among nursing students. To find out the association between level of knowledge score regarding telemedicine among nursing students and their selected socio-demographic variables. Material and Method: Investigator adopted a quantitative research approach with the Quasi-experimental research design (non-randomized control trial design). The subject were 100 nursing students and the non-probability purposive sampling method was used for selection criteria. Data was collected using socio-demographic data profile and self-structured knowledge questionnaire regarding telemedicine. A structured teaching programme regarding telemedicine was implemented in the experimental group after the pre-test, followed by the post-test after seven days. Data were analyzed using descriptive and inferential statistics. Result: In experimental group the mean knowledge score increased significantly from 20.26 (SD= 4.818) to 25.90 (SD = 1.446). this shows that the result was highly significant (t = 8.067, p < 0.001), indicating the intervention was effective. Whereas in control group there was no significant change in the knowledge score (Pre: 19.660, Post: 19.70, t = 0.096, p = 0.924), showing no impact without intervention. Conclusion: In the present study majority of the nursing students had Average level of knowledge regarding telemedicine in pretest. After implementing structured teaching program majority of the nursing students had good level of knowledge. Which indicates that the structured teaching programme was effective in enhancing the knowledge of nursing students regarding telemedicine.