A care bundle is a set of process that each aspect individually improves the patient outcome and should be performed together for all patients admitted in ICU. Objectives: 1. To assess the compliance of nurses on using infection control bundle in CCU. 2. To determine the association between the selected variables and the compliance of nurses on using infection control bundle in Critical care Unit. Method: A descriptive method was used to collect data from 30 nurses who were working in CCU of a selected Hospital, Chennai. The data was collected using the demographic and clinical variable Proforma & a rating scale to assess the steps while performing the care of the patient on the ventilator, central line catheter, and urinary catheterization. Results: The findings of the study revealed that there was no significant association between compliance of the nurses using infection control bundle in CCU. It is important for the nurses to follow this bundle, to prevent the infection like catheter-related bloodstream infection (CRBSI), ventilator-associated pneumonia (VAP), and catheter-associated urinary tract infection (CAUTI) and can provide optional care for the client. Discussion: The frequency percentage distribution of Compliance of Nurse in using Infection Control Bundle in CCU, shows that 12 staff nurses (73.3%) were good in the level of compliance and 8 staff nurses (26.6%) had averaged in the level of compliance.