This paper is published in Volume-6, Issue-1, 2020
Area
Msc Mlt
Author
Neethu V
Co-authors
Dr. Mohammed Rafiuddin Rashed, Fasalu Rahiman
Org/Univ
School of Health Sciences, Malappuram, Kerala, India
Pub. Date
17 January, 2020
Paper ID
V6I1-1188
Publisher
Keywords
Aspartate aminotranferase, Alanine aminotransferase, Alkaline phospatase, Superoxide dismutase, Glutathione reductase, Lipid peroxidase, Po-Per Oral, Aqueous Extract

Citationsacebook

IEEE
Neethu V, Dr. Mohammed Rafiuddin Rashed, Fasalu Rahiman. Assessment of anti-hepatotoxic potential and antioxidant defence status of aqueous extract of trachyspermumammi seeds to paracetamol hepatotoxicity in albino rats, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Neethu V, Dr. Mohammed Rafiuddin Rashed, Fasalu Rahiman (2020). Assessment of anti-hepatotoxic potential and antioxidant defence status of aqueous extract of trachyspermumammi seeds to paracetamol hepatotoxicity in albino rats. International Journal of Advance Research, Ideas and Innovations in Technology, 6(1) www.IJARIIT.com.

MLA
Neethu V, Dr. Mohammed Rafiuddin Rashed, Fasalu Rahiman. "Assessment of anti-hepatotoxic potential and antioxidant defence status of aqueous extract of trachyspermumammi seeds to paracetamol hepatotoxicity in albino rats." International Journal of Advance Research, Ideas and Innovations in Technology 6.1 (2020). www.IJARIIT.com.

Abstract

Aqueous extract of Trachyspermum Ammi seeds (AETAS) was evaluated for its hepatoprotective activities in rats. The plant extract (200 and 400mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against paracetamol-induced hepatotoxicity is judged from the serum marker enzymes and antioxidant level. Paracetamol - induced significant rise in AST, ALT, ALP, Total bilirubin with a reduction of total protein, albumin, SOD, Catalase, GSH and marked rise in LPO level. Treatment of rats with different doses of plant extracts (200 and 400mg/kg) significantly altered serum marker enzymes, antioxidant levels to near normal against paracetamol treated rats. The activity of the extracts was comparable to the standard drug silymarin (100mg/kg, p.o). Results indicate the hepatoprotective properties of (AETAS) against paracetamol-induced hepatotoxicity in rats.
Paper PDF