In India, oral cancer results in significant mortality and morbidity. Awareness about cancer, screening, early diagnosis, and treatment is the mainstay of management of oral cancer. There is very few evidence on the prevalence of oral cancer and oral pre-malignant lesion and awareness about them in Bihar. Therefore, this study was conducted with objectives to assess awareness about oral cancer, its risk factors and sign and symptoms among patients with oral pre-malignant lesions and to understand the determinants of awareness about oral cancer in Patna Bihar, India.