Background Majority of malignant diseases require therapy with chemotherapeutic agents for medium to long term time duration. Duration, feasibility and ease of placement, comfort, and rate of complications in patients are of utmost importance in choosing the type of catheter placement. In light of this peripherally inserted central venous catheters (PICC) have added advantage over conventional central venous catheters. The aim of this study was to evaluate the rate of infection related to PICC, the duration and outcome of PICC in oncological patients. Patients and Methods: A longitudinal study was conducted to look at the PICC (Peripherally Inserted Central Catheter)-related complication rates which occurred in inpatient and outpatient settings on patients who had a PICC line inserted for the administration of chemotherapeutic drugs, between 2015 to 2019, a period of five years. A total of 865 patients with PICC lines were analyzed. Pertinent patient demographics, as well as catheter-related factors, were collected. The data was analyzed by using excel and the association between duration and complication is compared using the chi-square test. p<0.05 is considered as significant.to identify catheter-related complications and the outcome of the PICC line in relation to the removal of the line. The Retrospective data analyzed so waiver of consent is taken on the day of PICC line insertion and the institutional ethical clearance has been taken for this study. As the data is taken retrospectively from the patient records with anonymity being maintained, no actual consent is required in this study. Approval from the hospital ethical committee got. Also during PICC insertion, informed consent is taken from all subjects. Results:s The PICCs placed for 865 patients, each between the duration of 3 months to 6 months was analyzed. The most suitable vein for the insertion was the basilic vein (85%). Conclusions: Our study suggests, PICC is an excellent option for various diagnostic and therapeutic interventions and offers clinicians and nurses a safe and effective option for central access. The data of this study shows PICC to be more cost-effective in terms of longer duration of use and have lower complication rates than the conventional CICCs and hence has to be promoted more in patients for chemotherapy drug administration.