Intermittent contagious disease outbreaks have had significant and enduring socioeconomic impacts throughout history. These occurrences have profoundly influenced and also have hundreds of thousands of years of physical, political, and social facets of human society. Outbreaks of epidemics have developed some of clinical medicine 's foundational values, which encourage the science world to evolve epidemiological, preventive, immunization and antimicrobial medicine concepts. Global public health is improving with leaps and bounds, but pandemics are not always unexpected. The diverse types of epidemiological shifts may be one of the key reasons in and around the world for such events. India has encountered several epidemics and pandemics throughout history. This paper talks about such outbreaks known to have occurred in the 19th – 21st century and are arranged in accordance with the chronology.