Hepatic encephalopathy (HE) is a significant neuropsychiatric syndrome linked to liver dysfunction, presenting as either minimal hepatic encephalopathy (MHE) or overt hepatic encephalopathy (OHE). This review is based on focused group discussions of various experts across India, followed by guidance statements based on analysis of published literature, and designing a set of comprehensive algorithms to encourage early detection, intervention, diagnosis, and management of HE, as well as improve patient outcomes. The experts recommended using tests like the Psychometric Hepatic Encephalopathy Score (PHES) and Critical Flicker Frequency (CFF) reliable tool for diagnosing MHE, highlighting the need for specialized neuropsychological testing. In addition, the experts discussed the role of lactulose and rifaximin in reducing HE recurrence, and the potential benefits of probiotics, prebiotics, and symbiotics. Furthermore, the experts emphasized the importance of nutritional management, particularly intake of protein and branched-chain amino acids (BCAA) in the overall HE management. Liver transplantation may be considered in refractory cases. Regular follow-ups are crucial to monitor and adjust treatment strategies. By incorporating expert opinions and evidence-based practices into the design of algorithms, the review aims to facilitate accurate and timely diagnosis, prompt intervention, and tailored treatment strategies, thereby reducing the variability in patient care, thus enhancing the quality of life for patients with HE.