A quasi-experimental research design was adopted to evaluate the effectiveness of the Information, Education, and Communication Package in terms of knowledge regarding management of selected side effects of chemotherapy were selected through a convenient sampling technique. The mean post-test score of knowledge among the experimental group was 19.81 (±2.46), whereas in the control group it was 13.53 (±3.66) that there was a significant difference (P<0.05) between pre and post the score.