Abstract: Osteoporosis is a silent, progressive disease characterized by decreased bone mass and structural deterioration, leading to an increased risk of fractures. Postmenopausal women are particularly vulnerable due to hormonal changes, especially the decline in estrogen levels. In India, the prevalence of osteoporosis is high among post-menopausal women, particularly in rural areas where awareness and access to preventive healthcare are limited. Educational interventions like structured teaching programs can help bridge the knowledge gap and promote preventive practices. Aim :To assess the effectiveness of a structured teaching program on knowledge regarding osteoporosis among post-menopausal women in selected areas of District Mandi, Himachal Pradesh. Materials and Methods: A pre-experimental, one-group pretest/post-test designwas adopted. A total of 100 post-menopausal women were selected through non- probability purposive sampling. A structured questionnaire was used to assess their knowledge regarding osteoporosis before and after the intervention. The structured teaching program included lectures, visual aids, and demonstrations related to osteoporosis prevention. Data were analysed using descriptive and inferential statistics; the effectiveness of the intervention was tested using the paired t-test, and associations with demographic variables were analysed using the chi-square test. Findings: Thepretest findings revealed that 5% had good knowledge ,29% ofwomen had poor knowledge, 66% had average knowledge. After the intervention, 62% demonstrated good knowledge, 38% had average knowledge, and none had poor knowledge. The mean knowledge score increased from 13.56 (SD = 4.76) in the pretest to 22.20 (SD = 3.43) in the post-test.The paired t-test showed a statistically significant improvement (t = 14.28, p = 0.00001*). A significant association was found between knowledge levels and variables such as occupation and type of family. Conclusion: The structured teaching program was effective in significantly enhancing the knowledge of post-menopausal women regarding osteoporosis. Educational interventions can play a critical role in promoting awareness and preventive practices, especially in rural settings where health literacy is low.