This paper is published in Volume-3, Issue-6, 2017
Area
UV Spectroscopic Method by Etoricoxib and Paracetamol Drug
Author
Yogesh S. Waghmare
Co-authors
Sonali P. Mahaparale
Org/Univ
Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India
Pub. Date
14 November, 2017
Paper ID
V3I6-1224
Publisher
Keywords
Etoricoxib, Paracetamol, Tablet Dosage forms, UV Spectrophotometry, Q-Analysis Spectroscopic method.

Citationsacebook

IEEE
Yogesh S. Waghmare, Sonali P. Mahaparale. A New Development and Validation of UV-Visible Spectrophotometric Method for Simultaneous Analysis of Etoricoxib and Paracetamol in Pharmaceutical and Bulk Dosage Forms, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Yogesh S. Waghmare, Sonali P. Mahaparale (2017). A New Development and Validation of UV-Visible Spectrophotometric Method for Simultaneous Analysis of Etoricoxib and Paracetamol in Pharmaceutical and Bulk Dosage Forms. International Journal of Advance Research, Ideas and Innovations in Technology, 3(6) www.IJARIIT.com.

MLA
Yogesh S. Waghmare, Sonali P. Mahaparale. "A New Development and Validation of UV-Visible Spectrophotometric Method for Simultaneous Analysis of Etoricoxib and Paracetamol in Pharmaceutical and Bulk Dosage Forms." International Journal of Advance Research, Ideas and Innovations in Technology 3.6 (2017). www.IJARIIT.com.

Abstract

The two methods for simultaneous estimation of Etoricoxib and Paracetamol in a combination of two drug tablet dosage form have been developed using Sodium Hydroxide (NaOH) as a solvent. The UV-visible Spectrophotometric was a determination using the simultaneous or operating of the same time equation method was a determination using the simultaneous equation method at 238.0 nm and 250.0 nm. The second UV Spectrometric method is the Q-analysis (absorption ratio) method, which involves the formation of absorbance equation at 243.0 nm (isoabsorptive point) and at 250.0 nm the maximum absorption of Paracetamol. The accuracy of the methods was assessed by recovery studies was found to be 100.3 ± 0.53 and 100.4 ± 0.80 for simultaneous equation method and 96.8 ± 0.55 and 98.18 ± 0.58 for Q analysis (absorption ratio) method for Etoricoxib and Paracetamol respectively. These methods are no complicated involved also corrected and rapid those require no in preparation of the more important separation and can therefore be used for routine analysis of both drugs. The linearity ranges for Etoricoxib and Paracetamol were 4-12μg/ ml and 2-18μg/ml respectively. The linearity ranges for Etoricoxib and Paracetamol were 2-18 μg/ml and 2-10 μg/ml respectively.
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