This paper is published in Volume-10, Issue-1, 2024
Area
Biotechnology
Author
Mayur Bagane, Dr. Rajesh Jorgewad, Goutam Jirage
Org/Univ
Kolhapur Institute of Technology's College of Engineering (Autonomous), Kolhapur, Maharashtra, India
Pub. Date
16 February, 2024
Paper ID
V10I1-1208
Publisher
Keywords
Dihydrofolate Reductase, Folate Metabolism, Cancer, Antibiotics, Autoimmune Diseases, Personalized Medicine.

Citationsacebook

IEEE
Mayur Bagane, Dr. Rajesh Jorgewad, Goutam Jirage. Dihydrofolate Reductase (DHFR): A Versatile Protein with Crucial Roles in Life and Disease, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARIIT.com.

APA
Mayur Bagane, Dr. Rajesh Jorgewad, Goutam Jirage (2024). Dihydrofolate Reductase (DHFR): A Versatile Protein with Crucial Roles in Life and Disease. International Journal of Advance Research, Ideas and Innovations in Technology, 10(1) www.IJARIIT.com.

MLA
Mayur Bagane, Dr. Rajesh Jorgewad, Goutam Jirage. "Dihydrofolate Reductase (DHFR): A Versatile Protein with Crucial Roles in Life and Disease." International Journal of Advance Research, Ideas and Innovations in Technology 10.1 (2024). www.IJARIIT.com.

Abstract

Dihydrofolate reductase (DHFR), a ubiquitous oxidoreductase, occupies a pivotal position in folate metabolism. This review presents a comprehensive analysis of DHFR's structure, catalytic mechanism, and diverse physiological roles. We highlight its essential function in purine and thymidylate biosynthesis, emphasizing its impact on DNA replication and cell proliferation. The review further explores the multifaceted implications of DHFR in disease: its exploitation in cancer chemotherapy through targeted inhibition, its role in bacterial antibiotic resistance, and potential associations with autoimmune disorders. Finally, we discuss emerging research avenues delving into novel DHFR inhibitors for cancer therapy, strategies to combat DHFR-mediated antibiotic resistance, and the exploration of DHFR gene polymorphisms in personalized medicine approaches for autoimmune diseases. This review underscores the critical role of DHFR in both normal cellular processes and various disease states, paving the way for future advancements in targeted therapeutic interventions.