Introduction: Mother is an important care provider and she is strongly responsible to the safety of the children. Children are the most vulnerable group of our population. Childhood accident is a sudden cause of death in children. Accident means “sudden, unexpected harmful event", An accident is often a harmful event that could be avoided by a little careful thought. Child accidents are very common among toddlers. Objectives: This study was done to assess the effectiveness of structure teaching programme regarding knowledge and practice of mothers. to assess the knowledge of mothers regarding prevention of accidents among toddlers, to assess the practice of mothers regarding prevention of accidents among toddlers, to find out the effectiveness of structured teaching program regarding knowledge and practices of mothers on the prevention of accidents among toddlers, to find out the association between the selected demographic variables with knowledge and practice score of mothers regarding prevention of accidents among toddlers. Material and Method: The present study has been carried out in Mashobra village and sample was included 320 mothers of toddlers. A structured questionnaire sheet was developed by the researcher to collect data. A simple random sampling approach was followed in this study and collection of data was performed by interviewing each mother at her home. The main results obtained from the study were as follows: most of the mothers were very poor knowledge of prevention of common accidents among toddlers and nearly all home had at least two or three potential environmental hazards. RESULTS: The present study revealed that the overall pre-test mean knowledge score of mothers regarding prevention of accidents among toddlers was found 31.67% and post test score was 73.33% in area of overall accidents, According to mothers practice in different type of accidents the present study indicated that the majority of mothers had 100% poor practice and post practice score was 62.5% mothers have moderate practice and 37.5% of mothers have good practice score regarding prevention of accidents among toddlers. After administration of STP the knowledge and practice level of mothers increased tremendously. The present study recommended health promotion classes about causes of accidents, first aid, preventive measures and safety for mothers at MCH center, in service educational program toward first aid should be established for community health nurses at rural health units and MCH center, a well planned health education program about causes of accidents, first aid and prevention introduced to the curriculum. Interpretation and Conclusion: The study findings revealed that structured teaching programme was highly effective in improving knowledge and practice of mothers regarding prevention of accidents among toddler. Key Word: Effectiveness, Knowledge, Practice, Structured teaching programme, toddler,